To open EndNote and create a new Library:
Select Start > All programs > EndNote Folder
> EndNote
If it is the first time you have used EndNote, select Create a new library.
To create a new library from within EndNote:
Your blank EndNote Library should open.
To open your existing Library:
If your Library is not appearing in the Recent list, go to File > Open... and browse to where you saved your Library.
Or
EndNote provides a sample Library (Sample_Library_X8) for you to explore.
To navigate to the 'Sample Library', browse to where you installed EndNote X8 and browse until you find Sample_Library_x8.enl:
File > Open Library > [browse to where you installed EndNote] then open EndNote X8 folder > Examples folder > Sample_Library_x8.enl.
If you did not specify where to install EndNote, it should be sitting in Program files (x86). Go to:
File > Open Library > Computer > Windows 7 > Program Files (x86) > EndNote X8 > Examples and choose the file Sample_Library_X8.enl.
Q: Can I create more than one Library?
A: Yes. But if you want to sync your references to EndNote Online, it is a best practice to only have one Library and organize your references into groups.
This is because you can only sync one EndNote Library per one EndNote Online account at a time. If you have more than one EndNote Library and wish to sync your references to EndNote Online, you will be prompted to merge Libraries.