To open EndNote and create a new Library:
Open Launchpad > Select EndNote Icon > EndNote will open
Nothing will open immediately until you create a new library or open an existing library.
If it is the first time you have used EndNote, you'll need to create a new library.
To create a new library in EndNote:
Your blank EndNote Library should open.
To open your existing Library, make sure EndNote is open, then:
If your Library does not appear in the Recent list, go to File > Open Library... and browse to where you saved your Library.
Or
Q: Can I create more than one Library?
A: Yes. But if you want to sync your references to EndNote Online, it is a best practice to only have one Library and organize your references into groups.
This is because you can only sync one EndNote Library per one EndNote Online account at a time. If you have more than one EndNote Library and wish to sync your references to EndNote Online, you will be prompted to merge Libraries.